Interactions between amyloid beta and CSF1R in ageing brains

 
   Lead Investigator:    Jun Xu
   Institution      :    Beijing Tiantan Hospital
   E-Mail           :    neurojun@126.com
   Proposal ID      :    990



   Proposal Description:
   Our team now is aiming to investigate to the interactions between amyloid beta and CSF1R during the ageing brains, which include Alzheimer?s Disease. We hypothesize that the degenerated microglia failed to clean Abeta regulated by CSF1R signaling pathway. Further, the function of microglia could be restored by the CRISPRed CSF1R gene allogenic mesenchymal stem cells (MSCs) transplantation. The animal experiments with transgenic APP/PS1 mutant mice have shown strong positive results including proteomics data, which need to be further verified by AD patients' brain samples.